WHEN IT'S TIME TO TAKE ACTION, THERE'S NUBEQA
NUBEQA is a pill for prostate cancer that has not spread to other parts of the body and no longer responds to a medical or surgical treatment that lowers testosterone.

Pill not actual size.
HOW NUBEQA WORKS
Within every prostate cell, there are special molecules called androgen receptors, or ARs for short. When testosterone attaches to an AR, it causes cancer cells to grow. NUBEQA attaches to the AR and blocks testosterone from attaching to it, which helps delay cancer growth.

Androgen Receptors

Testosterone attaches to an AR, causing prostate cancer cells to grow

NUBEQA blocks testosterone from attaching to the AR, helping to delay the cancer cell from growing

NUBEQA IS CLINICALLY PROVEN
NUBEQA HAS BEEN PROVEN TO WORK IN THE LARGEST CLINICAL TRIAL OF ITS KIND
NUBEQA was studied in a clinical trial with more than 1500 men with nmCRPC. In this study, 955 men added NUBEQA with hormone therapy* and 554 men received hormone therapy alone. This study measured the length of time living without the cancer spreading to other parts of the body, also called metastasis-free survival (MFS). The study also measured overall survival (OS), which is how long a person may live after starting therapy.
*Hormone therapy includes drug treatments or surgery that lowers testosterone.
nmCRPC=non-metastatic castration-resistant prostate cancer.
ADDING NUBEQA HELPS KEEP NON-METASTATIC PROSTATE CANCER THAT'S NO LONGER RESPONDING TO HORMONE THERAPY IN ITS PLACE
The study showed that men who added NUBEQA to their hormone therapy lived more than 2X longer without their prostate cancer spreading to other parts of the body than those who did not take NUBEQA.
NUBEQA MAY ALSO HELP YOU LIVE LONGER
The study also showed that NUBEQA significantly extended OS compared with hormone therapy alone.

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NUBEQA extended OS by lowering the risk of death by 31% compared with hormone therapy alone
ADDING NUBEQA TO HORMONE THERAPY OFFERS MEN THESE OTHER BENEFITS
NUBEQA GAVE MEN MORE TIME WITHOUT PAIN
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In a clinical trial, hormone therapy + NUBEQA relieved pain by nearly 15 months longer
– 40.3 months compared with 25.4 months (median) for hormone therapy alone
NUBEQA CAN DELAY THE START OF CHEMOTHERAPY
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In the same clinical trial, more men on hormone therapy + NUBEQA had not started chemotherapy at 3 years compared with men who stayed on hormone therapy alone
– 83% compared with 75% for hormone therapy alone
NUBEQA LOWERS PSA LEVELS
In a clinical study
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NUBEQA lowered PSA levels by an average of more than 90%
PSA=prostate-specific antigen.

With NUBEQA added to hormone therapy,
IT'S POSSIBLE TO LIVE 2X LONGER WITHOUT
YOUR PROSTATE CANCER SPREADING TO OTHER PARTS OF YOUR BODY.
POSSIBLE SIDE EFFECTS WITH NUBEQA IN PATIENTS WITH nmCRPC
NUBEQA can cause serious side effects including:
Heart disease. Blockage of the arteries in the heart (ischemic heart disease) that can lead to death has happened in some people during treatment with NUBEQA. Your healthcare provider will monitor you for signs and symptoms of heart problems during your treatment with NUBEQA. Call your healthcare provider or get medical help right away if you get chest pain or discomfort at rest or with activity, or shortness of breath during your treatment with NUBEQA.
Seizure. Treatment with NUBEQA may increase your risk of having a seizure. You should avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others. Tell your healthcare provider right away if you have loss of consciousness or seizure.
NUBEQA may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.
In a clinical study, when NUBEQA was added to hormone therapy* most men (84%) did not report feeling more tired than usual
The most common side effects of hormone therapy + NUBEQA vs hormone therapy alone are
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Feeling more tired than usual (16% vs 11% on hormone therapy alone)
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Pain in arm, leg, hand, or foot (6% vs 3% on hormone therapy alone)
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Rash (4% vs 1.4% on hormone therapy alone)
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Decreased white blood cells (neutropenia; 20% vs 9% on hormone therapy alone)
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Changes in liver function tests
Overall, serious side effects with hormone therapy + NUBEQA were moderately higher than those with hormone therapy alone.
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Serious side effects happened in 25% of men who added NUBEQA to hormone therapy compared to 20% who took hormone therapy alone
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Serious side effects that happened in 1% or more of men who added NUBEQA to their hormone therapy included: not being able to urinate completely, pneumonia, and blood in the urine
Sometimes side effects can cause a person to stop treatment when another treatment is added.
In a clinical trial, the tolerability profile of NUBEQA enabled most men to stay on therapy
There was no difference in the percentage of men (9%) who permanently stopped treatment due to side effects between those who took hormone therapy + NUBEQA and those who took hormone therapy alone
– Side effects that caused men to permanently stop taking hormone therapy + NUBEQA were heart failure (0.4%) and death (0.4%)That means most men (more than 90%) did not permanently stop taking NUBEQA due to side effects, similar to men who took hormone therapy alone
13% of men had to stop taking NUBEQA and then start it again because of side effects
– The most common reasons were high blood pressure (hypertension; 0.6%), diarrhea (0.5%), and pneumonia (0.5%)6% of men taking NUBEQA had to reduce their dosage because of side effects
– The most common reasons included fatigue (0.7%), high blood pressure (hypertension; 0.3%), and nausea (0.3%)
Talk to your doctor about the medicines you are taking
Although NUBEQA has a limited potential to interfere with other medicines, it may interfere with some medicines you are taking. So be sure to tell your doctor about all the medicines you are taking, including over-the-counter medicines and supplements.
*Hormone therapy includes drug treatments or surgery that lowers testosterone.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or by visiting www.FDA.gov/medwatch.
Always tell your doctor about any side effects you may have while taking NUBEQA.

DISCUSS SIDE EFFECTS with your
treatment team.
HOW TO TAKE NUBEQA
TAKE NUBEQA EXACTLY AS YOUR DOCTOR TELLS YOU
TAKE YOUR PRESCRIBED DOSE OF NUBEQA 2 TIMES A DAY WITH FOOD

NUBEQA Dosing: The recommended dose of NUBEQA is 600 mg (two 300 mg tablets) taken by mouth, twice daily.
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Swallow NUBEQA tablets whole
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If you miss a dose of NUBEQA, take your normal dose as soon as possible prior to the next scheduled dose
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Return to your normal schedule on the following day. Do not take 2 doses together to make up for a missed dose
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FOLLOW YOUR DOCTOR'S INSTRUCTIONS WHILE TAKING NUBEQA
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Your doctor may change your dose if needed. Do not stop taking your prescribed dose of NUBEQA without talking with your doctor first
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You should continue hormone therapy* during your treatment with NUBEQA unless you had surgery to lower the amount of testosterone in your body (surgical castration)
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If you take more NUBEQA than prescribed, call your healthcare provider right away
*Hormone therapy includes drug treatments or surgery that lowers testosterone.